EP1 receptor (pe2r1_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors EP1 receptor
GENE
PTGER1
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Prostaglandin E2 receptor EP1 subtype, PGE receptor EP1 subtype, PGE2 receptor EP1 subtype, Prostanoid EP1 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
P
|
C
|
G
|
P
|
L
|
N
|
L
|
S
|
10 |
L
|
A
|
G
|
E
|
A
|
T
|
T
|
C
|
A
|
A
|
20 |
P
|
W
|
V
|
P
|
N
|
T
|
S
|
A
|
V
|
P
|
30 |
TM1 | |||||||||
P
|
S
|
G
|
A
|
S
|
P
|
A
|
L
|
P
|
I
|
40 |
F
|
S
|
M
|
T
|
L
|
G
|
A
|
V
|
S
|
N
|
50 |
L
|
L
|
A
|
L
|
A
|
L
|
L
|
A
|
Q
|
A
|
60 |
ICL1 | TM2 | ||||||||
A
|
G
|
R
|
L
|
R
|
R
|
R
|
R
|
S
|
A
|
70 |
A
|
T
|
F
|
L
|
L
|
F
|
V
|
A
|
S
|
L
|
80 |
L
|
A
|
T
|
D
|
L
|
A
|
G
|
H
|
V
|
I
|
90 |
P
|
G
|
A
|
L
|
V
|
L
|
R
|
L
|
Y
|
T
|
100 |
ECL1 | TM3 | ||||||||
A
|
G
|
R
|
A
|
P
|
A
|
G
|
G
|
A
|
C
|
110 |
H
|
F
|
L
|
G
|
G
|
C
|
M
|
V
|
F
|
F
|
120 |
G
|
L
|
C
|
P
|
L
|
L
|
L
|
G
|
C
|
G
|
130 |
M
|
A
|
V
|
E
|
R
|
C
|
V
|
G
|
V
|
T
|
140 |
ICL2 | |||||||||
R
|
P
|
L
|
L
|
H
|
A
|
A
|
R
|
V
|
S
|
150 |
TM4 | |||||||||
V
|
A
|
R
|
A
|
R
|
L
|
A
|
L
|
A
|
A
|
160 |
V
|
A
|
A
|
V
|
A
|
L
|
A
|
V
|
A
|
L
|
170 |
ECL2 | |||||||||
L
|
P
|
L
|
A
|
R
|
V
|
G
|
R
|
Y
|
E
|
180 |
L
|
Q
|
Y
|
P
|
G
|
T
|
W
|
C
|
F
|
I
|
190 |
TM5 | |||||||||
G
|
L
|
G
|
P
|
P
|
G
|
G
|
W
|
R
|
Q
|
200 |
A
|
L
|
L
|
A
|
G
|
L
|
F
|
A
|
S
|
L
|
210 |
G
|
L
|
V
|
A
|
L
|
L
|
A
|
A
|
L
|
V
|
220 |
C
|
N
|
T
|
L
|
S
|
G
|
L
|
A
|
L
|
L
|
230 |
R
|
A
|
R
|
W
|
R
|
R
|
R
|
S
|
R
|
R
|
240 |
ICL3 | |||||||||
P
|
P
|
P
|
A
|
S
|
G
|
P
|
D
|
S
|
R
|
250 |
R
|
R
|
W
|
G
|
A
|
H
|
G
|
P
|
R
|
S
|
260 |
A
|
S
|
A
|
S
|
S
|
A
|
S
|
S
|
I
|
A
|
270 |
S
|
A
|
S
|
T
|
F
|
F
|
G
|
G
|
S
|
R
|
280 |
TM6 | |||||||||
S
|
S
|
G
|
S
|
A
|
R
|
R
|
A
|
R
|
A
|
290 |
H
|
D
|
V
|
E
|
M
|
V
|
G
|
Q
|
L
|
V
|
300 |
G
|
I
|
M
|
V
|
V
|
S
|
C
|
I
|
C
|
W
|
310 |
S
|
P
|
M
|
L
|
V
|
L
|
V
|
A
|
L
|
A
|
320 |
ECL3 | |||||||||
V
|
G
|
G
|
W
|
S
|
S
|
T
|
S
|
L
|
Q
|
330 |
TM7 | |||||||||
R
|
P
|
L
|
F
|
L
|
A
|
V
|
R
|
L
|
A
|
340 |
S
|
W
|
N
|
Q
|
I
|
L
|
D
|
P
|
W
|
V
|
350 |
H8 | |||||||||
Y
|
I
|
L
|
L
|
R
|
Q
|
A
|
V
|
L
|
R
|
360 |
Q
|
L
|
L
|
R
|
L
|
L
|
P
|
P
|
R
|
A
|
370 |
C-term | |||||||||
G
|
A
|
K
|
G
|
G
|
P
|
A
|
G
|
L
|
G
|
380 |
L
|
T
|
P
|
S
|
A
|
W
|
E
|
A
|
S
|
S
|
390 |
L
|
R
|
S
|
S
|
R
|
H
|
S
|
G
|
L
|
S
|
400 |
H
|
F
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGF2α, PGI2, PGD2, thromboxane A2, PGE1, PGE2
STRUCTURE MODELS
STRUCTURES
No structures available